When I had labradors, all I did was to shove the pills in the back of their throat as far back as possible, close their mouth, and hold my hand over their nose. It was easy breezy. The Mastiffs are different. They're a bit bigger, so it is tougher to do all that with them. I put the pills in peanut butter and they eat it willingly. If not, then I open their mouth and put the peanut buttered pills inside. They will then get so busy trying to swallow the sticky peanut butter with the pills, they don't have time to spit the pills out.